منابع مشابه
Pathophysiology of achalasia of the cardia.
The symptoms and signs of achalasia are due to the loss of ganglion cells in the body of the oesophagus, leading to dilatation and loss of peristaltic activity. The data pertaining to the lower oesophageal sphincter are still somewhat conflicting. The ganglion cells may be absent, but pharmacological evidence suggests denervation to be pre-ganglionic. The classical view of a normotensive, non-r...
متن کاملPathophysiology and Clinical Presentation of Achalasia
Achalasia of the oesophagus is a disease which has achieved more importance than would be expected, considering its extreme rarity. This is due partially to the excitement of seeing a large dilated oesophagus on x-ray but mainly because it demonstrates what can go wrong with normal physiology. The healthy oesophagus consists of a hollow muscular tube closed by a sphincter at each end, and is no...
متن کاملNew insights into the pathophysiology of achalasia and implications for future treatment
Idiopathic achalasia is an archetype esophageal motor disorder, causing significant impairment of eating ability and reducing quality of life. The pathophysiological underpinnings of this condition are loss of esophageal peristalsis and insufficient relaxation of the lower esophageal sphincter (LES). The clinical manifestations include dysphagia for both solids and liquids, regurgitation of eso...
متن کاملAchalasia.
Achalasia is the best understood and most readily treatable esophageal motility disorder. It serves as a prototype for disorders of the enteric nervous system with degeneration of the myenteric neurons that innervate the lower esophageal sphincter (LES) and esophageal body. Investigations into the pathogenesis have highlighted the importance of nitric oxide and the possible role of an autoimmun...
متن کاملAchalasia
Achalasia is a primary esophageal motor disorder characterized by lack of esophageal peristalsis and poor lower esophageal sphincter (LES) relaxation. Clinically, achalasia manifests as progressive dysphagia to solids and liquids and mild weight loss. Predisposition to esophageal cancer is not prevalent, but certain tumors may mimic achalasia. The diagnosis of achalasia is relatively easy to ma...
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ژورنال
عنوان ژورنال: Annals of Esophagus
سال: 2020
ISSN: 2616-2784
DOI: 10.21037/aoe-2019-ach-07